Natural Products Laboratory, Institute of Biology, Leiden University

2016 Publication List

  1. Antibiotic adjuvants from Buxus sempervirens to promote effective treatment of drug-resistant Staphylococcus aureus including biofilms. A. C. Abreu, D. Paulet, A. Coqueiro, J. Malheiro, A. Borges, M. J. Saavedra, Y. H. Choi, M. Simões. RSC Advances, 6, 95000-95009, 2016.
  2. Seasonal changes in strach content in trophopods of Matteuccia struthiopteris. P. Hovenkamp, S. -K. Yan, Y. H. Choi. American Fern Journal, 106, 153-160, 2016.
  3. Discrimination of wild types and hybrids of Duboisia myoporoides and Duboisia leichhardtii at different growth stages using 1H NM-based metabolite profiling and tropane alkaloids-tarted HPLC-MS analysis. S. F. Ullrich, N. J. H. Averesch, L. Castellanos, Y. H. Choi, A. Rothauer, O. Kayser. Phytochemistry, 131, 44-56, 2016.
  4. Metabolic changes in Euphorbia palusrtis latex after fungal infection of the plant. G. Krstić, B. Anđelković, Y. H. Choi, V. Vajs, T. Stević, V. Tešević, D. Gođevac. Phytochemistry, 131, 17-25 2016.
  5. Co-cultivation of Synechocystis salina and Pseudokirchneriella subcapitata under varying phosphorus concentration is evidence of an allelopathic competition scenario. A. L. Gonçalves, A. C. Abreu, A. Coqueiro, A. Gaspar, F. Borges, Y. H. Choi, J. C. M. Pires, M. Simões. RSC Advances, 6, 56091-56100, 2016.
  6. Metabolomic tool to identify antioxidant compounds of Fraxinus angustifolia leaf and stem bark extracts. K. Ayounia, M. Berboucha-Rahmani, H. K. Kim, D. Atmani, R. Verpoorte, Y. H, Choi. Industrial Crops Products, 88, 65-77, 2016.
  7. Culturing of Synechocystis sp. PCC6803 with N2/CO2 in a diel regime shows multi-phase glycogen dynamics and low maintenance costs. S. A. Angermayr, P. van Alphen, D. Hasdemir, G. Kramer, M. Iqbal, W. van Grondelle, H. C. Hoefsloot, Y. H. Choi, K. J. Hellingwer. Applied & Environmental Microbiology, 82, 4180-4189, 2016.
  8. Metabolomics-guided analysis of antibiotic production by Steptmyces specises MBT76 and biotransformation of phenylpropanoids. C. Wu, H. Zhu, G. P. van Wezel, Y. H. Choi. Metabolomics, 12, 90 (Article No.), 2016 (DOI: 10.1007/s11306-016-1025-6).
  9. Incorporation of an invasive plant into a native insect herbivore food web. M. Schilthuizen, L. P Santos Pimenta, Y. Lammers, P. J. Steenbergen, M. Flohil, N. G. P. Beveridge, P. T. van Duijn, M. M. Meulblok, N. Sosef, R. van de Ven, R. Werring, K. K. Beentjes, K. Meijer, R. A. Vos, K. Vrieling, B. Gravendeel, Y. H. Choi, R. Verpoorte, C. Smit, L. W. Beukeboom. PeerJ, 4, e1954, 2016 (DOI: 10.7717/peerj.1954).
  10. Anti-staphylococcal prenylated acylphloroglucinol and xanthones from Kielmeyera variabilis (Clusiaceae). A. Coqueiro, Y. H. Choi, R. Verpoorte, K. B. S. S. Gupta, M. De Mieri, M. Hamburger, M. C. M. Young, P. Stapleton, S. Gibbons, V. D. S. Bolzani. Journal of Natural Products, 79, 470-476, 2016.
  11. Monoterpenoid indole alkaloids biosynthesis and its regulation in Catharanthus roseus: a literature review from genes to metabolome. Q. Pan, N. R. Mustafa, K. Tang, Y. H. Choi, R. Verpoorte. Phytochemistry Reviews, 15, 221-250, 2016.
  12. Genotypic differences in metabolomic changes during storage induced-degreening of chrysanthemum disk florets. G. van Geest, Y. H. Choi, P. Arens, A. Post, Y. Liu, U. van Meeteren. Postharvest Biology and Technology, 115, 48-59, 2016.
  13. Metabolic profiling as a tool for prioritizing antimicrobial compounds. C. Wu, Y. H. Choi, G. V. van Wezel. Journal of Industrical Microbiology & Biotechnology, 43, 299-312, 2016.
  14. Metabolic effects of cannabinoids in zebrafish (Danio rerio) embryos determined by 1H NMR metabolomics. M. T. Akhtar, M. Y. Mushtaq, R. Verpoorte, M. K. Richardson, Y. H. Choi. Metabolomics, 12, 44 (Article No.), 2016 (DOI: 10.1007/s11306-016-0964-2.
  15. Application of natural deep eutectic solvents to the extraction of anthocyanins from Catharanthus roseus with high extractability and stability replacing conventional organic solvent. Y. Dai, E. Rozema, R. Verpoorte, Y. H. Choi. Journal of Chromatography A, 1434, 50-56, 2016.
  16. Metaboloic effects of carrier solvents and culture buffers in zebrafish (Danio rerio) embryos determined by 1H NMR metabolomics. M. T. Akhtar, M. Y. Mushtaq, M. K. Richardson, R. Verpoorte, Y. H. Choi. Omics, 20, 42-52, 2016.

2015 Publication List

  1. Expanding the chemical space for natural products by Aspergillus niger and Streptomyces coelicolor co-cultivation and biotransformation. C. Wu, B. Zacchetti, A. F. J. Ram, G. P. van Wezel, D. Claessen, Y. H. Choi. Scientific Reports, 5, 10868 (Article No.), 2015 (DOI: 10.1038/srep/10868).
  2. Probiotic supplementation influences faecal short chain fatty acids in infants at high risk for eczema. H. K. Kim, N. B. M. M. Rutten, I. Besseling-van der Vaart, L. E. M. Niers, Y. H. Choi, G. T. Rijkers, S. van Hemert. Beneficial Microbes, 6, 783-790, 2015.
  3. New phytochemicals from the corms of medicinally important South African Hypoxis species. K. Bassey, A. Viljoen, S. Combinck, Y. H. Choi. Phytochemistry Letters, 10, lxix–lxxv, 2015.
  4. Fungal endophytes of Vanilla planifolia across Réunion island: isolation, distribution and biotransformation. S. Khoyratty, J. Duppont, S. Lacoste, T. L. Palama, Y. H. Choi, H. K. Kim, B. Payer, M. Grisoni, M. Fouilaud, R. Verpoorte, H. Kodja. BMC Plant Biology, 2015, 15, 142-161.
  5. Extending pharmaocological dose-response curves for salsalate with natural deep eutectic solvents. E. Rozema, A. D. van Dam, H. C. M. Sips, R. Verpoorte, O. C. Meijer, S. Kooijman, Y. H. Choi. RSC Advances, 5, 61398-61401, 2015.
  6. Metabolomics-driven discovery of a prenylated isatin antibiotic produced by Streptomyces species MBT28. C. Wu, C. Cu, J. Grubbens, Y. H. Choi, G. van Wezel. Journal of Natural Products, 78, 2355-2363, 2015.
  7. Metabolomics analysis of Galium odoratum (L.) Scop.: Impact of the plant population origin and growth conditions. B. Marin, M. Frederich, P. de Tullio, J. –N. Wauters, Y. H. Choi, M. Bodson. Current Metabolomics, 3, 122-129, 2015.
  8. Metabolomics in the naural products field – a gateway to novel antibiotics. C. Wu, H. K. Kim, G. P. van Wezel, Y. H. Choi. Drug Discovery Today: Technologies, 13, 11-17, 2015.
  9. Investigation of chemomarkers of Astragali Radix from different ages and geographical origin by NMR profiling. L. Zheng, M. Wang, E. I. Estrada, C. S. Wu, E. G. Wilson, R. Verpoorte, P. G. L. Klinkhamer, Y. H. Choi. Molecules, 20, 3389-3405, 2015.
  10. Identification of novel endophenasides produces by Kitasatospora sp. MBT 66. C. Wu, G. P. van Wezel, Y. H. Choi. The Journal of Antibiotics, 68, 445-452, 2015.
  11. Metabolic alteratkons and distribution of five-carbon precursors in jasmonic acid-elicited Catharanthus roseus cell suspension cultures. M. Z. Saiman, N. R. Mustafa, Y. H. Choi, R. Verpoorte, A. E. Schulte. Plant Cell Tissue & Organ Culture, 122, 355-362, 2015.
  12. Tailoring properties of natural deep eutecic solvents with the addition of water to facilitate their applications. Y. Dai, R. Verpoorte, G. –J. Witkamp, Y. H. Choi. Food Chemistry, 187, 14-19, 2015.

2014 Publication List

  1. Environmentally benign supercirical CO2 extraction of galanthamine from floricultural crop waste of Narcissus pseudonarcissus. O. Rachmaniah, Y. H. Choi, I. Arruabarrena, B. Vermeulen, J. van Spronsen, R. Verpoorte, G.-J. Witkamp. The Journal of Supercritical Fluid, 93, 7-19, 2014
  2. Identification of adenosine A1 receptor ligands from Morus alba L. stem bark by NMR metabolomics approach. N. D. Yuliana, S. Budijanto, R. Verpoorte, Y. H. Choi. International Food Research Journal, 21, 1103-1107, 2014.
  3. Chemical interaction between plants in Mediterranean vegetation: the influence of selected plant extracts on Aegilops geniculata metabolome. M. Scognamiglio, V. Fiumano, B. D’Abrosca, A. Esposito, Y. H. Choi, R. Verpoorte, A. Firentiono. Phytochemistry, 106, 69-85, 2014.
  4. A quantitative proteomics-based platform to link natural products to gene clusters and identification of a novel juglomycin-type antibiotic. J. Gubbens, H. Zhu, G. Girard, L. Song, B. I. Florea, P. Aston, K. Ichinose, D. V. Filippov, Y. H. Choi, H. S. Overkleeft, G. L. Challis, G. P. van Wezel. Chemistry and Biology, 21, 2-12, 2014.
  5. What you see is what you extract. Y. H. Choi, R. Verpoorte. Phytochemical Analysis, 25, 289-290, 2014.
  6. Eliciting antibiotics active against the ESKAPE pathogens in an ecologically defined collection of actinomycetes. H. Zhu, J. Swierstra, C. Wu, G. Girard, Y. H. Choi, G. P. van Wezel. Microbiology, 160, 1714-1725, 2014.
  7. Quantitative analysis of amygdalin and prunasin in Prunus serotina Ehrh. using 1H NMR Spectroscopy. L. P. Santos Pimenta, M. Schilthuizen, R. Verpoorte, Y. H. Choi. Phytochemical Analysis, 25, 122-126, 2014.
  8. Investigation of the chemomarkers correlated with flower color in different organs of Catharanthus roseus using NMR-based metabolomics. Q. Pan, Y. Dai, T. R. Nuringtyas, N. R. Mustafa, A. E. Schulte, R. Verpoorte, Y. H. Choi. Phytochemical Analysis, 25, 66-74, 2014.
  9. Natural deep eutectic solvents providing enhanced stability of natural colarants from safflower (Carthamus tinctorius). Y. Dai, R. Verpoorte, Y. H. Choi. Food Chemistry, 159, 116-121, 2014.
  10. Effect of acute stresses on Zebrafish (Danio rerio) metabolome measured by NMR-based metabolomics. M. Y. Mushtaq, R. M. Marçal, D. L. Champagne, F. van der Kooy, R. Verpoorte, Y. H. Choi. Planta Medica, 80, 1227-1233, 2014.
  11. Analysis of metabolites in the terpenoid pathway of Catharanthus cell suspension. M. Z. Saiman, N. R. Mustafa, B. Pomahočová, M. Verberne, R. Verpoorte, Y. H Choi, A. E. Schulte. Plant Cell Tissue & Organ Culture, 117, 225-239, 2014.
  12. Extraction for metabolomics: The access to the metabolome. M. Y. Mushtaq, Y. H. Choi, R. Verpoorte, E. G. Wilson. Phytochemical Analysis, 25, 291-306, 2014.
  13. Perturbation of polyamine catabolism affects grape ripening of Vitis vinifera cv. Trincadeira. P. Agudelo-Romero, K. Ali, Y. H. Choi, L. Sousa, R. Verpoorte, A. F. Tiburcio, A. M. Fortes. Plant Physiology and Biochemistry, 74, 141-155, 2014.
  14. Effect of temperature and pressure on extraction of plant metabolites: model experiments using Solanum tuberosum and Senecio jacobaea leaves. M. –S. Kim, M. Iqbal, R. Verpoorte, P. G. L. Klinkhame, Y. H. Choi. Chemical and Pharmaceutical Bulletin, in submission, 2014.

2013 Publication List

  1. Ionic liquids and deep eutectic solvents in natural products research. Y. Dai, J. Van Spronsen, G. –J. Witkamp, R. Verpoorte, Y. H. Choi. Journal of Natural Products, 76, 2162-2173, 2013.
  2. Natural deep eutectic solvents as a new extraction media for phenolic metabolites in Carthamus tinctorius L. Y. Dai, G. –J. Witkamp, R. Verpoorte, Y. H. Choi. Analytical Chemistry, 85, 6272-6278, 2013.
  3. Identification of bioactive metabolites against adenosine A1 receptor using NMR-based Metabolomics. K. Ali, M. Iqbal, N. D. Yuliana, Y. -J Lee, S. Park, S. Han, J. –W. Lee, H. –S. Lee, R. Verpoorte, Y. H. Choi. Metabolomics, 9, 778-785, 2013.
  4. Seasonal accumulation of major alkaloids in organs of pharmaceutical crop Narcissus Carlton. A. Lubbe, H. Gude, R. Verpoorte, Y. H. Choi. Phytochemistry, 88, 43-53, 2013.
  5. NMR metabolomics for identification of adenosine A1 receptor binding compounds from Boesenbergia rotunda rhizomes extract. N. D. Yuliana, S. Budijanto, R. Verpoorte, Y. H. Choi. Journal of Ethnopharmacology, 150, 95-99, 2013.
  6. Metabolic fingerprinting of Tomato Mosaic Virus infected Solanum lycopersicum. M. P. Lopez-Gresa, P. Lison, H. K.Kim, Y. H. Choi, R. Verpoorte, I. Rodrigo, V. Conejero, J. M. Bells. Journal of Plant Physiology, 169, 1586-1596, 2013.
  7. Limitation of Mitragynine Biosynthesis in Mitragyna speciosa (Roxb.) Korth. through tryptamine availability. T. Charoonratana, P. Pathompak, N. Keawpradub, M. I. Georgiev, Y. H. Choi, R. Verpoorte, J. Wungsintaweekul. Zeitschrift für Naturforshung C, 10, 283-293, 2013.
  8. Collection and trade of wild-harvested orchids in Nepal. A. Subedi, B. Kunwar, Y. H. Choi, Y. Dai, T. van Andel, R. P. Chaudhary, H. J. de Boer, B. Granvendeel. Journal Ethanobiology and Ethnomedicine. 9, 64-73, 2013.
  9. Plant bioassay to assess the effects of allelochemicals on the metabolome of the target species Aegilops geniculata by a NMR-based approach. B. D’Abrosca, M. Scognamiglio, V. Fiumano, A. Esposito, Y. H. Choi, R. Verpoorte, A. Fiorentino. Phytochemisry, 93, 37-40, 2013.
  10. Metabolomics for the rapid dereplication of bioactive compounds from natural sources. N. D. Yuliand, M. Jahangir, R. Verpoorte, Y. H. Choi. Phytocemistry Reviews, 12, 293-304, 2013.
  11. Plant metabolomics: from holistic data to relevant biomarkers. J. –L. Wolfender, S. Rudaz, Y. H. Choi, H. K. Kim. Current Medicinal Chemistry, 20, 1056-1090, 2013.
  12. Natural Deep Eutectic Solvents as New Potential Media for Green Technology. Y. Dai, J. van Spronsen, G. -J. Witkamp, R. Verpoorte, Y. H. Choi. Analytica Chimica Acta, 766, 61-68, 2013.
  13. Red wines attenuate TNFα production in human histiocytic lymphoma cell line: An NMR spectroscopy and chemometrics based study. K. Ali, M. Iqbal, A. M. Fortes, M. S. Pais, H. A. A. J. Korthout, R. Verpoorte, Y. H. Choi. Food Chemistry, 141, 3124-3130, 2013.

2012 Publication List

  1. Red wines attenuate TNFα production in human histiocytic lymphoma cell line: An NMR spectroscopy and chemometrics based study. K. Ali, M. Iqbal, A. M. Fortes, M. S. Pais, H. A. A. J. Korthout, R. Verpoorte, Y. H. Choi. Food Chemistry, accepted, 2012.
  2. Overexpression of ORCA3 and G10H in Catharantus roseus plants regulated alkaloid biosynthesis and metabolismo revealed by NMR-metabolomics. Q. Pan, Q. Wang, F. Yuan, S. Xing, J. Zhao, Y. H. Choi, R. Verpoorte, Y. Tian, G. Wang, K. Tang. PLOS ONE, in press, 2012.
  3. Metabolomics changes in Narcissus bulbs induced by fungicide applications. A. Lubbe, R. Verpoorte, Y. H. Choi. Plant Physiology and Biochemistry, 58, 116-127, 2012.
  4. A comparison on the metabolic profiling of the Mexican anxiolytic and sedative plant Galphimia glauca four years later. A. Sharma, A. Cardoso-Taketa, Y. H. Choi, R. Verpoorte, M. L. Villarreal. Journal of Ethanopharmacology, 141, 964-974, 2012.
  5. Differential tissue distribution of metabolites in jacobaea vulgaris, jacobae aquatica and their crosses. T R. Nuringtyas, Y. H. Choi, R. Verpoorte, P. G. L. Klinkhamer, K. A. Leiss. Phytochemistry, 78, 89-97, 2012.
  6. Metabolic profiling of tomato mosaic virus infected Solanum lycopersicum. M. Pilar López-Gresa, P. Lisón, H. K. Kim, Y. H. Choi, R. Verpoorte, I. Rodrigo, J., M. Bellés, V. Conejero. Journal of Plant Physiology, 169, 1586-1596, 2012.
  7. Metabolomic plasticity in GM and non-GM potato leaves in response to aphid herbivory and virus infection. A. Plischke, Y. H. Choi, P. M. Brakefield, P. G. L. Klinkhamer, M. Bruinsma. Journal of Agricultural and Food Chemistry, 60, 1488-1493, 2012.
  8. Metabolic Fingerprinting by 1H NMR for discrimination of the two species used as Radix Bupleuri. X. Qin1 Y. Dai, N. Q. Liu, Z. Li, X. Liu, J. Hu, Y. H. Choi, R. Verpoorte. Planta Medica, 78, 926-933, 2012.
  9. Alterations in grapevine leaf metabolism upon inoculation with Plasmapora viticola. K. Ali, F. Maltese, A. Figueiredo, M. Rex, A. M. Fortes, E. Zyprian, M. S. Pais, R. Verpoorte, Y. H. Choi. Plant Science, 191-192, 100-107, 2012.
  10. Induction and characterization of adventitious root cultures from leaf explants of Gynura procumbens. M. Z. Saiman, N. R. Mustafa, A. E. Schulte, R. Verpoorte, Y. H. Choi. Plant Cell Tissue & Organ Culture, 109, 465-475 2012.
  11. Metabolomic plasticity in GM and non-GM potato leaves in response to aphid herbivory and virus infection. A. Plischke, Y. H. Choi, P. M. Brakefield, P. G. L. Klinkhamer, M. Bruinsma. Journal of Agricultural and Food Chemistry, in press, 2012.
  12. 12. NMR spectroscopy and chemometrics as a tool for anti-TNFα activity screening in crude extracts of grapes and other berries. K. Ali, M. Iqbal, H. A. A. J. Korthout, F. Maltese, A. M. Fortes, M. S. Pais, R. Verpoorte, Y. H. Choi. Metabolomics, in press, 2012.
  13. Metabolomics in Practice: NMR-based metabolomics analysis In Metabolomics in Practice Successful Strategies to Generate and Analyze Metabolic Data (eds by M. Lämmerhofer and W. Weckwerth), pp. , A. Lubbe, K. Ali, R. Verpoorte, Y. H. Choi, Wiley-VCH, 2012, Weinheim.
  14. Metabolite analysis of Cannabis sativa L. by NMR spectroscopy In Functional Genomics Methods and Protocols. (eds by M. Jaufmann and C. Klinger). Metthods in Molecular Biology 815. Pp. 363-376. Humana Press. 2012, New York.

2011 Publication List

  1. Transgressive segregation of primary and secondary metabolites in F2 hybrids between Jacobaea aquatica and J. vulgaris. H. Kirk, D. Cheng, Y. H. Choi, K. Vrieling, P. G. L. Klinkhamer. Metabolomics, 8, 211-219, 2011.
  2. Comprehensive extraction method integrated with NMR metabolomics - a new bioactivity screening method for plants: adenosine A1 receptor binding compounds in Orthosiphon stamineus Benth. N. D. Yuliana, A. Khatib, R. Verpoorte, Y. H. Choi. Analytical Chemistry, 83, 6902-6906, 2011.
  3. Transcript and metabolite analysis during ripening of Trincadeira grapes highlights cultivar specificities. A. M. Fortes, P. Agudelo-Romer, M. S. Silva, K. Ali, F. Maltese, Y. H. Choi, L. Sousa, J. Grimplet, J. Zapater, R. Verpoorte, M. S. Pais. The BMC Plant Biology, 11, 149-182, 2011.
  4. Metabolic differentiations and classification of Verbascum species by NMR-based metabolomics. M. I. Georgiev, K. Ali, K. Alipieva, R. Verpoorte, Y. H. Choi. Phytochemistry, 70, 2045-2051, 2011.
  5. Pre-analytical method for NMR-based grape metabolic fingerprinting and chemometrics. K. Ali, F. Maltese, A. M. Fortes, M. S. Pais, Robert Verpoorte, Y. H. Choi. Analytica Chimica Acta, 703, 179-186, 2011.
  6. Are Natural Deep Eutectic Solvents the Missing Link in Understanding Cellular Metabolism and Physiology? Y. H. Choi, J. van Spronsen, Y. Dai, M. Verberne, F. Hollmann, I. W. C. E. Arends, G.-Jan Witkamp, R. Verpoorte. Plant Physiology, 156, 1701-1705, 2011.
  7. Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa roots. W.-T. Chang, Y. H. Choi, R. Van der Heijden, M.-S. Lee, M.-K. Lin, H. Kong, H. K. Kim, R. Verpoorte, T. Hankemeier, J. Van Der Greef, M. Wang. Chemical Pharmaceutical Bulletin, 59, 546-552, 2011.
  8. Comprehensive review on herbal medicine for energy intake suppression. N. D. Yuliana, M. Jahangir, H. Korthout, Y. H. Choi, H. K. Kim, R. Verpoorte. Obesity Reviews, 12, 499-514, 2011.
  9. Metabolic fingerprinting reveals differences between wild and cultivated carrots (Daucus carota L.) shoots and suggest maternal inheritance or wild trait dominance in hybrids. C. Grebenstein, Y. H. Choi, J. Rong, T. J. de Jong, W.L.M. Tamis. Phytochemistry, 72, 1341-1347, 2011.
  10. Metabolic characterization of green Pods from Vanilla planifolia accessions grown in La Réunion. T. L. Palama, A Khatib, Y. H. Choi, B. Côme, I. Fock, R. Verpoorte, Hippolyte Kodja. Environmental and Experimental Botany, 72, 258-265, 2011.
  11. Effect of fertilizers on galanthamine and metabolite profiles in Narcissus bulbs by 1H NMR. A. Lubbe, P. Vreeburg, Y. H. Choi, R. Verpoorte. Journal of Agricultural and Food Chemistry, 59, 3155-3161, 2011.
  12. NMR-based plant metabolomics: where do we stand, where do we go? H. K. Kim, Y. H. Choi, R. Verpoorte. Trends in Biotechnology, 29, 267-275, 2011.
  13. Metabolic characterization of Palatinate German wines according to sensory attributes, varieties, and vintages using NMR spectroscopy and multivariate data analyses. K. Ali, F. Maltese, R. Toepfer, Y. H. Choi, R. Verpoorte. Journal of Biomelcular NMR, 49, 255-266 2011.

2010 Publication List

  1. Metabolic classification of Ilex Species by NMR-based metabolomics. H. K. Kim, Saifullah, Saifullah Khan, E. G. Wilson, S. D. Prat Kricun, A. Meissner, S. Göraler, A. M. Deelder, Y. H. Choi, R. Verpoorte. Phytochemistry, 71, 773-784, 2010.
  2. Metabolic fingerprinting of Cannabis sativa L., cannabinoids and terpenoids for chemotaxonomic and drug standardization purposes. J. T. Fischedick, A. Hazekamp, T. Erkelens, Y. H. Choi, R. Verpoorte. Phytochemistry, 71, 2058-2073, 2010, 2010.
  3. Glucosinolate profiling of Brassica rapa cultivars in response to infection by Leptosphaeria maculans and Fusarium oxysporum. I. B. Abdel-Farid, M. Jahangir, N. R. Mustafa, N. van Dam, C. A. M. J. J. van den Hondel, H. K. Kim, Y. H. Choi, R. Verpoorte. Biochemical Systematics and Ecology, in press, 2010.
  4. Monitoring biochemical changes during grape berry development in Portuguese cultivars by NMR spectroscopy. K. Ali, F. Maltese, A. M. Fortes, M. S. Pais, Y. H. Choi, R. Verpoorte. Food Chemistry, 124, 1760-1769, 2010.
  5. Metabolic changes of Brassica rapa transformed with bacterial isochorismate synthase gene. S. Simoh, H. J. M. Linthorst, A. W. M. Lefeber, C. Erkelens, H. Kyong Kim, Y. H. Choi, R. Verpoorte. Journal of Plant Physiology, in press, 2010.
  6. Metabolic Constituents of Grapevine and Grape-Derived Products. K. Ali, F. Maltese, Y. H. Choi, Robert Verpoorte. Phytochemistry Reviews, 9, 357-378, 2009.
  7. Comparative analysis on the quantitation of artemisinin with chromatography based and qNMR techniques. F. van der Kooy, N.-Q. Liu, Y. H. Choi, R. Verpoorte. Phytochemical Analysis, in press, 2010.
  8. Metabolic analysis of elicited cell suspension cultures of Cannabis sativa L. by 1H-NMR spectroscopy. J. Peč, I. J. Flores-Sancheza, Y. H. Choi, R. Verpoorte. Biotechnology Letters, 32, 935-941, 2010.
  9. Metabolic alterations in different developmental stages of Pilocarpus microphyllus. I. N. Abreu; Y. H. Choi, C. H. F. Alexandra; M. N. Eberlin; P. Mazzafera, R. Verpoorte. Planta Medica, accepted, 2010.
  10. Metabolomics for bioactivity assessment of natural products. N. D. Yuliana, A. Khatib, Y. H. Choi, R. Verpoorte. Phytotheraphy Research, in press, 2010.
  11. Shoot differentiation from protocorm callus cultures of Vanilla planifolia (Orchidaceae): proteomic and metabolic responses at early stage.T. L. Palama, P. Menard, I. Fock, Y. H. Choi, E. Bourdon, J. Govinden-Soulange, M. Bahut, B. Payet, R. Verpoorte, H. Kodja. The BMC Plant Biology, in press, 2010.
  12. Metabolomics: a tool for anticancer lead-finding from natural products. H. K. Kim, E. G. Wilson, Y. H. Choi, R. Verpoorte. Planta Medica, in press, 2010.
  13. Metabolomics: will it stay. R. Verpoorte, Y. H. Choi, H. K. Kim. Phytochemical Analysis, 21, 2-3, 2009.
  14. NMR-based metabolomic analysis of plants. H. K. Kim, Y. H. Choi, R. Verpoorte. Nature Protocols, 3, 536-549, 2010.
  15. Biological Variation of Vanilla planifolia Leaves Metabolome. T. L. Palama, I. Fock, Y. H. Choi, R. Verpoorte, H. Kodja. Phytochemistry, 71, 567-573, 2010.
  16. Metabolomic investigation of the ethnopharmacological use of Artemisia afra with NMR Spectroscopy and Multivariate Data Analysis. N. Q. Liu, M. Cao, M. Frédérich, Y. H. Choi, R. Verpoorte, F. van der Kooy. Journal of Ethnopharmacology, 128, 230-235, 2010.
  17. Metabolomics: what’s new? R. Verpoorte, Y. H. Choi, H. K. Kim. Flavor and Fragrance Journal, 25, 128-131, 2010.
  18. NMR-based metabolomics to identify secondary plant compounds involved in host plant resistance to thrips. K. A. Leiss, Y. H. Choi, R. Verpoorte, P. G. L. Klinkhamer. Phytochemistry Reviews, in press, 2010.

2009 Publication List

  1. NMR metabolic fingerprinting-based identification of grapevine metabolites associated with downy mildew resistance. K. Ali, F. Maltese, Y. H. Choi, E. Zyprian, M. Rex, R. Verpoorte. Journal of Agricultural and Food chemistry, 57, 9599-9606, 2009.
  2. Metabolomic analysis of host plant resistance to thrips in wild and cultivated tomatoes. M. Mirnezhad, R. R. Romero-González, K. A. Leiss, Y. H. Choi, R. Verpoorte, P. G. L. Klinkhamer. Phytochemical Analysis, 21, 110-117, 2009.
  3. An ABC transporter mutation alters root exudation of phytochemicals that provokes an overhaul of natural soil microbiota. D. V. Badri, N. Quintana, E. El Kassis, H. K. Kim, Y. H. Choi, R. Verpoorte, E. Martinoia, D. K. Manter, J. M. Vivanco. Plant Physiology, 151, 2006-2017, 2009.
  4. Metabolic response of tomato leaves upon different plant-pathogen interactions. M. P. López-Gresa, F. Maltese, J. M. Bellés, V. Conejero, H. K. Kim, Y. H. Choi, R. Verpoorte. Phytochemical Analysis, 21, 89-94, 2009.
  5. Phenolic constituents of Gnaphalium uliginosum. A. N. Shikov, M. Kundracikova, T. L. Palama, O. N. Pozharitskaya, V. M. Kosman, V. G. Makarov, B. Galambosi, H. J. Kim, Y. P. Jang, Y. H. Choi, R. Verpoorte. Phytochemistry Letters, 3, 45-47, 2009.
  6. Metabolic changes of salicylic acid-elicited Catharanthus roseus cell suspension cultures monitored by NMR-based metabolomics. N. R. Mustafa, H. K. Kim, Y. H. Choi, R. Verpoorte. Biotechnology Letters, 31, 1967-1974, 2009.
  7. Metabolic changes in different developmental stages of Vanilla planifolia pods. T. L. Palama, A. Khatib, Y. H. Choi, I. Fock, B. Payet, R. Verpoorte, H. Kodja. Journal of Agricultural and Food chemistry, 57, 7651-7658, 2009.
  8. Analysis of metabolic variation and galanthamine content in Narcissus bulbs by 1H NMR. A. Lubbe, B. Pomahačová, Y. H. Choi, R. Verpoorte. Phytochemical Analysis, 21, 66-72, 2009.
  9. Healthy and unhealthy plants: The effect of stress on the metabolism of Brassicaceae. M. Jahangir, I. B. Abdel-Farid, H. K. Kim, Y. H. Choi, R. Verpoorte. Environmental and Experimental Botany, 67, 23-33, 2009.
  10. Genotype-environment interactions affect flower and fruit herbivory and plant chemistry of Arabidopsis thaliana in a transplant experiment. A. M. Arany, T. J De Jong, H. K. Kim, N. M. Van Dam, Y. H. Choi, H. G. J. Van Mil, R. Verpoorte, E. Van Der Meijden. Ecological Research, 24, 1161-1171, 2009.
  11. Elicitation studies in cell suspension cultures of Cannabis sativa L. I. J. Flores-Sancheza, J. Peč, J. Fei, Y. H. Choi, J. Dušek, R. Verpoorte. Journal of Biotechnology, 143, 157-168, 2009.
  12. Identification of chlorogenic acid as a resistance factor for thrips in chrysanthemum. K. A. Leiss, F. Maltese, Y. H. Choi , R. Verpoorte, P. G. L. Klinkhamer. Plant Physiology, 150, 1567-1575, 2009.
  13. NMR metabolomics of thrips resistance in Senecio hybrid. K. A. Leiss, Y. H. Choi, I. B. Abdel-Farid, R. Verpoorte, P. G. L. Klinkhamer. Journal of Chemical Ecology, 35, 219-229, 2009.
  14. Effect of benzothiadiazole on the metabolome of Arabidopsis thaliana. T. T. H. Dao, R. C. Puig, H. K. Kim, C. Erkelens., A. W. M. Lefeber, H. J. M. Linthorst, Y. H. Choi, R. Verpoorte. Plant Physiology and Biochemistry, 47, 146-152, 2009.
  15. Adenosine A1 receptor antagonist activity of methoxy flavonoids from Orthosiphon stamineus. N. D. Yuliana, A. Khatib, A. M. R. Link-Struensee, A. P. Ijzerman, Y. H. Choi, R. Verpoorte. Planta Medica, 75, 132-136, 2009.
  16. Biosynthesis of salicylic acid in fungus elicited Catharanthus roseus cells. N. R. Mustafa, H. K. Kim, Y. H. Choi, C. Erkelens, A. W. M. Lefeber, G. Spijksma, R. van der Heijden, R. Verpoorte. Phytochemistry, 70, 532-539, 2009.
  17. Identification of natural enantiomeric flavanone glycosides by NMR spectroscopy. F. Maltese, C. Erkelens, F. van der Kooy, Y. H. Choi, R. Verpoorte. Food Chesmitry, 116, 575-579, 2009.
  18. Fungal infection-induced metabolites in Brassica rapa. I. B. Abdel-Farid, M. Jahangir, H. K. Kim, Y. H. Choi, R. Verpoorte. Plant Science, 176, 608-615, 2009.
  19. Metabolic changes in Agrobacterium tumefaciens –infected Brassica rapa. S. Simoh, N. Quintana, H. K. Kim, Y. H. Choi, R. Verpoorte. Journal of Plant Physiology, 166, 1005-1014, 2009.
  20. Quality control of herbal material and phytopharmaceuticals with MS and NMR based metabolic fingerprinting. F. van der Kooy, F. Maltese, Y. H. Choi, H. K. Kim, R. Verpoorte. Planta Medica, 75, 763-775, 2009.
  21. Health affecting compounds in Brassicaceae. M. Jahangir, H. K. Kim, Y. H. Choi, R. Verpoorte. Comprehensive Reviews in Food Science and Food Safety, 8, 31-43, 2009.

2008 Publication List

  1. Organogenic nodule development in hop (Humulus lupulus L.): transcript and metabolic responses. A. M. Fortes, F. Santos, Y. H. Choi, A. Figueiredo, M. S. Silva, L. Sousa, F. Pessoa, B. Acioli, M. Sebastiana, K. Palme, R. Malhó, R. Verpoorte, M. S. Pais. The BMC Genomics, 9, 445-472, 2008.
  2. Metal ions-inducing metabolites accumulation in Brassica rapa. M. Jahangir, Ibrahim Bayoumi Abdel-Farid, Y. H. Choi, R. Verpoorte. Journal of Plant Physiology, 165, 1429-1437, 2008.
  3. Transcriptional and metabolic profiling of Vitis vinifera L. cultivars’ leaves: Unravelling Regent’s innate resistance capabilities. A. Figueiredo, A. M. Fortes, S. Ferreira, M. Sebastiana, Y. H. Choi, L. Sousa, B. Acioli, F. Pessoa, R. Verpoorte, M. S. Pais. Journal of Experimental Botany, 59, 3371-3381, 2008.
  4. Preanalytical method for metabolic profiling of plant cell cultures of Passiflora garckei. M. Fraccaroli, S. Nicoletti, F. Maltese, Y. H. Choi, F. Guzzo, M. Levi, R. Verpoorte. Biotechnology Letters, 30, 2031-2036, 2008.
  5. Metabolomic profiling of the Mexican anxiolytic and sedative plant Galphimia glauca using nuclear magnetic resonance spectroscopy and multivariate data analysis. A. T. C. Taketa, R. Pereda-Miranda, Y. H. Choi, R. Verpoorte, M. L. Villarreal. Planta Medica, 74, 1295-1301, 2008.
  6. NMR Metabolomic Analysis of Fecal Water from Subjects on a Vegetarian Diet. J. Pettersson, P. C. Karlsson, Y. H. Choi, R. Verpoorte, J. J. Rafter, L. Bohlin. Biological and Pharmaceutical Bulletin, 31, 1192-1198, 2008.
  7. Metabolomics: back to basics. R. Verpoorte, Y. H. Choi, R. N. Mustafa, H. K. Kim. Phytochemistry Reviews, 7, 525-537, 2008.
  8. Single step purification of salicylic acid from Catharanthus roseus cell culture (plant material) by anion exchange for NMR analysis. N. R. Mustafa, H. K. Kim, Y. H. Choi, R. Verpoorte. Journal of Liquid Chromatography Related Technologies, 31, 702-713, 2008.
  9. Recent methodology in the phytochemical analysis of ginseng. N. Angelova, H. –W. Kong, R. Van der Heijden, S. –Y. Yang, Y. H. Choi, H. K. Kim, M. Wang, T. Hankemeier, J. Van der Greef, G. Xu, R. Verpoorte. Phytochemical Analysis, 19, 2-16, 2008.
  10. Metabolomic response of Brassica rapa submitted to pre-harvest bacterial contamination. M. Jahangir, H. K. Kim, Y. H. Choi, R. Verpoorte. Food Chemistry, 107, 362-368, 2008.
  11. Glucosinolates and other metabolites in leaves of Arabidopsis thaliana from natural populations and their effects on a generalist and a specialist Herbivore. A. Mosleh Arany, T. J. De Jong, H. K. Kim, N. M. Van Dam, Y. H. Choi, R. Verpoorte, E. Van Der Meijden. Chemoecology, 18, 65-71, 2008.

2007 Publication List

  1. NMR-based metabolomics at work in phytochemistry. R. Verpoorte, Y. H. Choi, H. K. Kim. Phytochemistry Reviews, 6, 3-14, 2007.
  2. Metabolic characterization of Brassica rapa leaves by NMR spectroscopy. I. B. Abdel-Farid, H. K. Kim, Y. H. Choi, R. Verpoorte. Journal of Agricultural and Food Chemistry, 55, 7936-7943, 2007.
  3. Metabolomic alterations in elicitor treated Silybum marianum suspension cultures monitored by nuclear magnetic resonance spectroscopy. A. Sánchez-Sampedro, H. K. Kim, Y. H. Choi, R. Verpoorte, P. Corchete. Journal of Biotechnology, 130, 133-142, 2007.
  4. NMR Assignment of Iso--acids from isomerised extracts of Humulus lupulus L. cones. A. Khatib, E. G. Wilson, H. K. Kim, M. Supardi, Y. H. Choi, R. Verpoorte. Phytochemical Analysis, 18, 371-377, 2007.

2006 Publication List

  1. The role of secondary metabolites in Arabidopsis and Brassica in the interaction with fungi. I. B. Abdel-Farid, Y. H. Choi, H. K. Kim, C. A. M. J. J. van den Hondel, E. van der Meijden, R. Verpoorte. Current Topics in Plant Biology, 7, 47-73, 2006.
  2. Metabolomics: Novel tool for studying complex biological systems. R. Verpoorte, Y. H. Choi, H. K. Kim. Chemical Senses 31, E67, 237 October, 2006.
  3. Activity of Quinones from Teak (Tectona grandis) on Fungal Cell Wall Stress. P. Sumthong, R. A. Damveld, Y. H. Choi, M. Arentshorst, A. F. J. Ram, C. A. M. J. J. van den Hondel, R. Verpoorte. Planta Medica, 72, 943-944, 2006.
  4. NMR metabolomics to revisit the tobacco mosaic virus infection in Nicotiana tabacum leaves. Y. H. Choi , H. K. Kim, H. J. M. Linthorst, J. G. Hollander, A. W. M. Lefeber, C. Erkelens, J.-M. Nuzillard, R. Verpoorte. Journal of Natural Products, 69, 742-748, 2006.
  5. Metabolomic differentiation of Brassica rapa leaves attacked by herbivore using two dimensional nuclear magnetic resonance spectroscopy. H. T. Widarto, E. van der Meijden, A. W. M. Lefeber, C. Erkelens, H. K. Kim, Y. H. Choi, R. Verpoorte. Journal of Chemical Ecology, 32, 2417-2428, 2006.
  6. Metabolomic analysis of methyl jasmonate treated Brassica rapa leaves by two dimensional NMR spectroscopy and multivariate analysis. Y. –S. Liang, Y. H. Choi, H. K. Kim, H. J. M. Linthorst, R. Verpoorte. Phytochemistry, 67, 2503-2511, 2006.
  7. Metabolic differentiation of Arabidopsis treated with methyl jasmonate using nuclear magnetic resonance spectroscopy. O. Hendrawati, Q. Yao, H. K. Kim, H. J. M. Linthorst, C. Erkelens, A. W. M. Lefeber, Y. H. Choi, R. Verpoorte. Plant Science, 170, 1118-1124, 2006.
  8. Application of two dimensional J-resolved nuclear magnetic resonance spectrum to differentiation of beer. A. Khatib, E. G. Wilson, H. K. Kim, A. W. M. Lefeber, C. Erkelens, Y. H. Choi, R. Verpoorte. Analytica Chimica Acta, 559, 264-270, 2006.
  9. Identification of phenylpropanoids in Brassica rapa leaves treated with methyl jasmonate using two-dimensional nuclear magnetic resonance spectroscopy. Y. -S. Liang, H. K. Kim, A. W. M. Lefeber, C. Erkelens, Y. H. Choi, R. Verpoorte. Journal of Chromatography A, 1112, 148-155, 2006.
  10. Application of two dimensional nuclear magnetic resonance spectroscopy to quality control of ginseng commercial products. S. Y. Yang, H. K. Kim, A. W. M. Lefeber, C. Erkelens, N. Angelova, Y. H. Choi, R. Verpoorte. Planta Medica, 72, 364-369, 2006.
  11. Plants as source of medicine: New perspectives In Medicinal and aromatic Plants (eds by R.J. Bogers, L.E. Craker and D.Lange), pp. 261-273, R. Verpoorte, H. K. Kim, Y. H. Choi, Springer, 2006, Amsterdam.
  12. Metabolomics In Medicinal Plant Biotechnology From Basic Research to Industrial Applications (eds by O. Kayser and W. Quax), pp. 9-28, Y. H. Choi, H. K. Kim, R. Verpoorte, Wiley-VCH, 2006, Weinheim.
  13. Metabolomic analysis of Catharanthus roseus using NMR and principal component analysis In Plant Metabolomics (eds by K. Saito, R. A. Dixon, and L. Willmitzer), pp. 261-276, H. K. Kim, Y. H. Choi, R. Verpoorte, Springer, 2006, Berlin.

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